Understanding the Role of Mechanical Forces in Periodontal Homeostasis

About This Course

Learn about the role of mechanical forces and extracellular matrix in periodontal homeostasis with this course. Discover how collagen and POSTN contribute to homeostasis and potential targets for therapy. Limitations and future directions are also discussed.

Why Take This Course?

The course addresses a common problem faced by UK dental professionals, which is the management of periodontal disease. Periodontal disease is a chronic inflammatory condition that affects the tissues surrounding and supporting the teeth. Mechanical forces and extracellular matrix play a crucial role in maintaining periodontal homeostasis, and any disturbance in this balance can lead to disease progression. The course provides insights into the molecular mechanisms involved in periodontal homeostasis and the potential targets for periodontal therapy. It also discusses the limitations of current treatments and future directions in this field.

This course is beneficial for understanding the role of mechanical forces and extracellular matrix in periodontal homeostasis, and discussing potential targets for periodontal therapy.

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How This Course Supports GDC Enhanced Dental CPD

“Dental professionals have a duty to keep their knowledge and skills up to date. A primary qualification is only the first step in their education and development which should last throughout their professional life” General Dental Council

Learning Objectives	Anticipated Outcomes
1: By the end of this course, students will be able to analyze and describe the role of mechanical forces in periodontal homeostasis.	1: By the end of this course, students will be able to analyze the role of mechanical forces in periodontal homeostasis.
2: Upon completion, learners will have the capacity to differentiate between the effects of compressive and shear forces on extracellular matrix protein expression in periodontal ligament stem cells.	2: Upon completion, learners will have the capacity to evaluate histological changes in hypofunctional teeth.
3: Students will demonstrate their ability to interpret and evaluate histological changes in hypofunctional teeth and their impact on periodontal ligament space.	3: Students will demonstrate their ability to interpret the effects of mechanical forces on extracellular matrix protein expression in periodontal ligament stem cells.
4: By the final session, participants will have mastered the understanding of laminin expression and its relationship with fluid shear forces in the periodontal ligament.	4: By the final session, participants will have mastered the understanding of laminin expression and its relationship to fluid shear forces.
5: At the course’s conclusion, attendees will have developed the competency to critically compare and contrast the hypofunctional tooth model with the hyperfunctional tooth model in terms of periodontal disease progression.	5: At the course’s conclusion, attendees will have developed the competency to identify potential targets for periodontal therapy based on ECM protein deposition and modulation.

Regulatory Standards

GDC	CQC
✅ A – Effective Communication ✅ B – Effective Management ✅ C – Maintenance in Field of Practice ✅ D – Maintenance in Patient Confidence	✅ Caring ✅ Effective ✅ Leadership ✅ Responsive ✅ Safe

🕐 60 minutes of Enhanced Dental CPD

Course Description

This course covers the role of mechanical forces and extracellular matrix in periodontal homeostasis, with lessons on the effect of forces on protein expression and histological changes in hypofunctional teeth. It also includes a discussion on the role of collagen and POSTN in homeostasis and potential targets for periodontal therapy. The course concludes with limitations and future directions.

Course Outline

Section 1

The first section of this course provides an overview of periodontal ligament and extracellular matrix, the role of mechanical forces in periodontal homeostasis, a hypofunctional tooth model in rats, study aims and methodology, and case study analysis of periodontal disease progression.

Section 2

The course content in Section 2 covers the in vitro results of the study, including the effect of forces on ECM protein expression in PDLSCs, the increase of POSTN expression under compressive and shear forces, and the decrease of collagen I expression with force. It also includes a thought experiment on force magnitude and direction.

Section 3

In Section 3, the course covers the in vivo results of the study, including histological changes in hypofunctional teeth, narrowing of the periodontal ligament space, decreased collagen I and POSTN expression, laminin expression around blood vessels, and microCT analysis of periodontal space width.

Section 4

Section 4 of the course discusses the role of collagen I and POSTN in periodontal homeostasis, POSTN modulation of collagen turnover, laminin expression and fluid shear forces, differences in root locations, and a comparison to the hyperfunctional model.

Section 5

Section 5 of this course covers the conclusion of the study, including the impact of deficiency on ECM protein deposition, the role of mechanical forces in modulating ECM composition, potential targets for periodontal therapy, limitations and future directions, and a summary of the implications of the study.

Course Reviews

⭐⭐⭐⭐⭐
This course provided valuable insights into the link between mechanical forces and periodontal homeostasis, with practical lessons on protein expression and histological changes in hypofunctional teeth.

✅ Met Course Objectives

✅ Met Course Outcomes

✅ Would Recommend

✅ Had Positive Impact

⭐⭐⭐⭐⭐
The course content was both informative and engaging, with a thorough discussion on the role of collagen and POSTN in homeostasis and potential targets for periodontal therapy.

✅ Met Course Objectives

✅ Met Course Outcomes

✅ Would Recommend

✅ Had Positive Impact

⭐⭐⭐⭐⭐
Overall, this course was an excellent resource for dental professionals seeking to deepen their understanding of the mechanisms behind periodontal disease and potential treatments.

✅ Met Course Objectives

✅ Met Course Outcomes

✅ Would Recommend

✅ Had Positive Impact

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